Circulating metabolites are associated with brain atrophy and white matter hyperintensities
نویسندگان
چکیده
منابع مشابه
White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy
This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5-T MRI. CSF Aβ42 and total tau were measured (n = 353). Brain and hippocampal loss we...
متن کاملWhite matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease.
BACKGROUND AND OBJECTIVE Methodological variability in the assessment of white matter hyperintensities (WMH) in dementia may explain inconsistent reports of its prevalence and impact on cognition. We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer's disease (AD) and examined the association between WMH and structural and cognitive variables. ME...
متن کاملWhat are White Matter Hyperintensities Made of?
1. On page 3, the right column, first full paragraph, the third sentence read, “A large multicenter study of WMH in 2699 stroke patients in 11 stroke centers in China suggested....” It has been changed to read, “A large multicenter study of WMH in 2699 stroke patients in 11 stroke centers in Korea suggested....” 2. On page 5, the left column, the third complete sentence read, “A recent very lar...
متن کاملWhat are White Matter Hyperintensities Made of?
W hite matter hyperintensities (WMH) of presumed vascular origin, also referred to as leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or computed tomography (CT) in older subjects and in patients with stroke and dementia. They are associated with cognitive impairment, triple the risk of stroke and double the risk of dementia. Knowledge of their pathology deriv...
متن کاملCirculating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities.
BACKGROUND AND PURPOSE White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634). METHODS We measured plasma fibrinogen, C-reactive p...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2020
ISSN: 1552-5260,1552-5279
DOI: 10.1002/alz.12180